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Chromosome-level organization of the regulatory genome in the Drosophila nervous system [Hi-C]

ABSTRACT: Here we present evidence for a new level of genome folding, whereby distant domains megabases apart fuse to form meta-domains. Within meta-domains, certain gene promoters pair with structural intergenic elements in the distant TAD. These long-range associations occur in a large fraction of Drosophila neurons, but support transcription in only a subset of cells in the nervous system. Most of the associated genes encode neuronal determinants, including those engaged in axonal guidance and adhesion. Meta-domains are formed by diverse transcription factors that are able to pair over long and flexible distances. We present evidence that one of these factors, GAF, plays a direct role in this process.

ORGANISM(S): Drosophila melanogaster Drosophila virilis

PROVIDER: GSE214704 | GEO | 2023/08/01

REPOSITORIES: GEO

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