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Chromosome-level organization of the regulatory genome in the Drosophila nervous system [scATAC-seq]

ABSTRACT: We present evidence for a new level of genome folding, whereby distant domains megabases apart fuse to form meta-domains. Within meta-domains, certain gene promoters pair with structural intergenic elements in the distant TAD. These long-range associations occur in a large fraction of Drosophila neurons, but support transcription in only a subset of cells in the nervous system. Most of the associated genes encode neuronal determinants, including those engaged in axonal guidance and adhesion. We used single cell assay for transposase-accessible chromatin using sequencing (scATAC-seq) to identify regions of open chromatin at single cell resolution.

ORGANISM(S): Drosophila melanogaster

PROVIDER: GSE214705 | GEO | 2023/08/01

REPOSITORIES: GEO

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