Transcriptomics

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Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner I

ABSTRACT: Loss of SAMHD1 causes chronic activaiton of the MDA5/MAVS dsRNA sensing pathway, only when cGAS/STING signaling is intact. Peritoneal macrophages from mutant and control mice were isolated by FACS. Total RNA was subjected to next generation mRNA sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE214711 | GEO | 2022/10/10

REPOSITORIES: GEO

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