Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner II
Ontology highlight
ABSTRACT: Loss of SAMHD1 causes chronic activaiton of the MDA5/MAVS dsRNA sensing pathway, only when cGAS/STING signaling is intact. Peritoneal macrophages from mutant and control mice were isolated by FACS. Total RNA was subjected to next generation mRNA sequencing.
ORGANISM(S): Mus musculus
PROVIDER: GSE214712 | GEO | 2022/10/10
REPOSITORIES: GEO
ACCESS DATA