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Ethanol and its nonoxidative metabolites promote acute liver injury by inducing ER stress, adipocyte death and lipolysis

ABSTRACT: We gave mice either a 5g/kg ethanol (EtOH) gavage, a 7g/kg EtOH gavage, or an isocaloric maltose gavage (equivalent to 5g/kg EtOH) in the morning and sacrificed mice 9h later. Microarray analyses were performed on liver tissue from these mice to determine genes and pathways contributing to acute ethanol-induced liver injury. Lipid metabolism-associated genes were found to be dysregulated in both the 5g/kg and 7g/kg groups, with the majority of changes occuring in the 7g/kg group. Genes related to fatty acid metabolism were most changed in the 7g/kg group compared to control and 5g/kg groups.

ORGANISM(S): Mus musculus

PROVIDER: GSE214778 | GEO | 2022/10/07

REPOSITORIES: GEO

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