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Differential ribosome engagement profiling between undifferentiated and neuron-differentiated P19 cells

ABSTRACT: Translation is tightly regulated during differentiation. To gain insights into the mechanism regulating translational activity at the transcript level, we performed Ribosome Profiling of undifferentiated and neuron-differentiated P19 cells. Relative changes in translational activity between the undifferentiated and differentiated cells show an increase in the translational activity of the transcripts encoding for ribosomal proteins compared to the rest of the transcriptome. Thus, in this differentiation system, the biogenesis of the translational machinery is tightly controlled at the translational level.

ORGANISM(S): Mus musculus

PROVIDER: GSE214816 | GEO | 2023/08/04

REPOSITORIES: GEO

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