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Post-transcriptional regulation of Ribosome Biogenesis during differentiation [dRNA-seq]

ABSTRACT: Ribosome biogenesis is a critical component of cell differentiation. Ribosome synthesis has been previously reported to be highly regulated at the transcriptional level, but less is known about its post-transcriptional regulation. Poly(A) tail length regulation is a hallmark of post-transcriptional regulation associated with transcript stability. Here we monitor poly(A) tail length changes at a transcriptome level during P19 differentiation. We found that poly(A) tail shortening occurs during cell differentiation only for transcript encoding for ribosomal proteins. These findings suggest a strong post-transcriptional regulation of ribosome biogenesis during differentiation.

ORGANISM(S): Mus musculus

PROVIDER: GSE214874 | GEO | 2023/08/04

REPOSITORIES: GEO

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Post-transcriptional regulation of Ribosome Biogenesis upon treatment with MHY1485

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