Transcriptomics

Dataset Information

0

Apolipoprotein A1-Manipulated Cholesterol Efflux Subverts the Phagocytic Fragility of TAMs and Improves Oncolytic Viro-Immunotherapy in Glioblastoma [BMDMs RNA-seq]


ABSTRACT: We found that TAMs in the glioblatoma (GBM) tumor microenvironment are enriched for cholesterol and highly express ABCA1/G1. To investigate the biological effects of enhancing cholesterol efflux of TAMs in GBM, we constructed APOA1-overexpressing GL261 cell line. We harvested tumor tissue and sorted these TAMs by anti-mouse F4/80 magnetic beads 17 days after intracranial transplantation of GL261-APOA1 cell line and control cells in immunocompetent C57 mice. Samples were subjected to transcriptome sequencing.

ORGANISM(S): Mus musculus

PROVIDER: GSE214907 | GEO | 2022/10/09

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-05-04 | GSE201975 | GEO
2022-05-04 | GSE201976 | GEO
| PRJNA833881 | ENA
2022-05-04 | GSE201977 | GEO
| PRJNA833879 | ENA
| PRJNA833882 | ENA
2022-12-28 | GSE221777 | GEO
2020-09-16 | GSE158016 | GEO
2012-04-01 | E-GEOD-34903 | biostudies-arrayexpress
2022-03-31 | GSE193814 | GEO