Transcriptomics

Dataset Information

0

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae


ABSTRACT: Post-acute sequelae of SARS-CoV-2 infection are debilitating, clinically heterogeneous, and of unknown molecular etiology. A transcriptome-wide investigation was performed in acutely infected patients followed clinically into the post-acute period. Distinct gene-expression signatures of post-acute sequelae were already present in whole-blood during acute infection, with innate and adaptive immune cells implicated in different symptoms. Two clusters of sequelae exhibited divergent plasma-cell associated gene-expression patterns. In one cluster, sequelae associated with higher expression of immunoglobulin-related genes in an anti-spike antibody titer-dependent manner. In the other, sequelae associated independently of these titers with lower expression of immunoglobulin-related genes, indicating lower non-specific antibody production in subjects with these sequelae. This relationship between lower total immunoglobulins and sequelae was validated in an external cohort. Altogether, multiple etiologies of post-acute sequelae were already detectable during SARS-CoV-2 infection, directly linking these sequelae with the acute host response to the virus and providing early insights into their development.

ORGANISM(S): Homo sapiens

PROVIDER: GSE215865 | GEO | 2022/12/06

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2013-05-28 | E-GEOD-11704 | biostudies-arrayexpress
2023-05-15 | GSE224955 | GEO
2023-07-11 | GSE236562 | GEO
2023-04-30 | GSE230301 | GEO
2024-01-12 | MTBLS850 | MetaboLights
2024-06-28 | GSE268812 | GEO
2024-06-28 | GSE268810 | GEO
2013-05-28 | GSE11704 | GEO
2023-07-03 | PXD041973 | Pride
2023-07-03 | PXD041777 | Pride