The circadian clock protein Cryptochrome 1 is a direct target and feedback regulator of the Hippo pathway
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ABSTRACT: To examine the impact of Cry1 downregulation on gene expression, empty vector (Sh Ctrl) and Sh-RNA targeting Cry1 (Sh Cry1) were used to produce lentiviral vector. Cell were then infected with control and sh-RNA lentivirus and then selected with puromycin. Upon validation of the knockdown with real time PCR. RNA were prepared from cells stably expressing empty vector or sh-RNA against Cry1 and used gene expression profiling by RNA seq. RNA of two biological replicate were prepared from each genotype.
ORGANISM(S): Homo sapiens
PROVIDER: GSE216975 | GEO | 2023/08/01
REPOSITORIES: GEO
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