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An interferon gamma response signature links myocardial aging and immunosenescence

ABSTRACT: Aging entails profound immunological transformations that can negatively impact the myocardial biology and predispose to myocardial diseases. However, preclinical research in the immune-cardiology field is mostly conducted in young healthy animals, which potentially weakens its translational relevance. Herein, we sought to investigate how the aging T-cell compartment impacts myocardial cell biology in elderly. By investigating the paired-wised age-related shifts in the heart and its draining lymph nodes, our study provides evidence for an increased myocardial IFN-gamma signaling, which is associated with inflammatory and metabolic shifts typically seen in heart failure (HF).

ORGANISM(S): Mus musculus

PROVIDER: GSE217098 | GEO | 2023/03/10

REPOSITORIES: GEO

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