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SARS-CoV-2 mouse adaptation generates a gain of function that causes TNF driven age-dependent severe disease with human correlates

ABSTRACT: To dissect the nature of the immune dysregulation induced by SARS-CoV-2 infection in mouse lungs using mouse-adapted strains of the virus. Comparisons were performed using bulk RNA-seq data from mouse (C57BL/6) lung homogenates taken 3 days post-infection with mouse-adapted SARS-CoV-2, both early and late (virulent) passages, or mock-infected mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE217556 | GEO | 2023/11/09

REPOSITORIES: GEO

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