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Effect of long-term exposure of platinum nanopariticles on gene expression of Pseudomonas aeruginosa PAO1

ABSTRACT: Previous synthesized Pt NPs were selected to evaluate the influences on bacterial resistance, and a typical pathogenic microbe P. aeruginosa was chosen as model bacteria. After 60-day PtNPs exposure, we found under 12.5 μg/mL of platinum nanoparticles (PtNPs) exposure for ~7200 generations, the IC50 of evolved Pseudomonas aeruginosa PAO1 to imipenem (IPM) and ciprofloxacin (CIP) reduced 77.0% and 87.8%, respectively. Interestingly, long-term of PtNPs exposure arose the bacterial susceptibility on antibiotics. We then performed gene expression profiling analysis using data obtained from RNA-seq.

ORGANISM(S): Pseudomonas aeruginosa

PROVIDER: GSE218408 | GEO | 2023/12/01

REPOSITORIES: GEO

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