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Genome-wide characterization of PhoB binding profile in Escherichia coli

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Escherichia coli Escherichia coli str. K-12 substr. MG1655

PROVIDER: GSE21857 | GEO | 2012/10/21

SECONDARY ACCESSION(S): PRJNA127075

REPOSITORIES: GEO

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Genome-wide characterization of PhoB binding profile in Escherichia coli

Project description:This SuperSeries is composed of the following subset Series: GSE21820: Genome-wide characterization of PhoB binding profile in Escherichia coli (gene expression data) GSE21856: Genome-wide characterization of PhoB binding profile in Escherichia coli (ChIP-chip data) Refer to individual Series

2012-10-21 | E-GEOD-21857 | biostudies-arrayexpress

Genome-wide characterization of PhoB binding profile in Escherichia coli (ChIP-chip data)

Project description:Chromatin immunoprecipitation was combined with high-density tiling array (ChIP-chip) and gene expression microarray to reveal the adaptive responses of Escherichia coli to phosphate starvation. The first sketch of the genome-wide distribution of PhoB binding profile was unveiled and 43 regions were identified as the PhoB binding regions. The presence of a significant common motif in these binding regions allowed us to reconstruct the PhoB binding pattern. By comparing the ChIP-chip and microarray datasets, we were also able to identify genes directly or indirectly affected through PhoB regulation. Nineteen out of the 287 differentially expressed genes in the presence and absence of PhoB activity were considered as the genes directly regulated by PhoB. The adaptive responses affected through PhoB regulation are discussed and these responses involve in several important biological functions including transcriptional regulation, transportation, membrane component arrangement, sigma factor modulation and DNA replication inhibition.

2012-10-21 | GSE21856 | GEO

Genome-wide characterization of PhoB binding profile in Escherichia coli (gene expression data)

2012-10-21 | GSE21820 | GEO

Genome-wide characterization of PhoB binding profile in Escherichia coli (gene expression data)

2012-10-21 | E-GEOD-21820 | biostudies-arrayexpress

Genome-wide characterization of PhoB binding profile in Escherichia coli (ChIP-chip data)

2012-10-21 | E-GEOD-21856 | biostudies-arrayexpress