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Effect of Combination Therapy with Anti-PD-1 Antibody and dasatinib on Liver Metastases in an Experimental Mouse Model

ABSTRACT: In order to investigate whether dasatinib, a stromal inhibitor, could increase the sensitivity to immunotherapy for metastatic colorectal cancer, we generated a mouse model of liver metastasis. We performed a comprehensive gene expression profiling analysis by extracting toral RNA from liver metastases of mice treated with immunotherapy alone or with immunotherapy and dasatinib.

ORGANISM(S): Mus musculus

PROVIDER: GSE218603 | GEO | 2022/11/28

REPOSITORIES: GEO

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