The SARS-CoV-2 Spike protein modifies the transcriptional profile of human cardiac pericytes
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ABSTRACT: Human cardiac pericytes express the receptors for SARS-CoV-2 and contribute to microvascular dysfunction in COVID-19 patients. The SARS-CoV-2 capsid Spike protein seems to play a direct role in COVID-19 microangiopathy, but it is not known yet whether the Spike protein alone, without the infectious virus, can induce transcriptional alterations in pericytes. This study investigated the signalling pathways activated by the Spike protein in cultured human cardiac pericytes. We found that 309 RNA transcripts were significantly modulated in pericytes exposed to the Spike protein, with the upregulation of pathways linked to inflammation and viral infection.
ORGANISM(S): Homo sapiens
PROVIDER: GSE218644 | GEO | 2023/05/09
REPOSITORIES: GEO
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