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Characterisation of the functional and transcriptomic effects of pro-inflammatory cytokines on human EndoC-βH5 beta cells

ABSTRACT: EndoC-βH5 is a newly established human beta-cell model which may be superior to previous models of native human beta cells. Exposure of beta cells to proinflammatory cytokines is a widely used in vitro model of immune-mediated beta-cell failure in type 1 diabetes and we therefore performed an in-depth characterisation of the effects of cytokines on EndoC-βH5 cells. Global gene expression was characterised by stranded RNA sequencing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE218735 | GEO | 2023/04/01

REPOSITORIES: GEO

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