Ontology highlight
ABSTRACT:
SUBMITTER: Ke R
PROVIDER: S-EPMC4488346 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Ke Ruian R Loverdo Claude C Qi Hangfei H Sun Ren R Lloyd-Smith James O JO
PLoS computational biology 20150630 6
Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical ...[more]