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Transcriptome and epigenome analysis of DIAMOND mice (ChIP-Seq)

ABSTRACT: The purpose of this experiment is to characterize changes in the transcriptome and epigenome in diet-associated liver cancer. For that we used the DIAMOND mice as a model organism and performed RNA-seq and H3K27Ac and H3K27Me3 ChIP-seq in livers from control mice (fed with a regular diet) and livers and tumours from western diet fed mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE220576 | GEO | 2024/10/23

REPOSITORIES: GEO

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Transcriptome and epigenome analysis of DIAMOND mice (RNA-Seq)

Project description:The purpose of this experiment is to characterize changes in the transcriptome and epigenome in diet-associated liver cancer. For that we used the DIAMOND mice as a model organism and performed RNA-seq and H3K27Ac and H3K27Me3 ChIP-seq in livers from control mice (fed with a regular diet) and livers and tumours from western diet fed mice.

2024-10-23 | GSE220575 | GEO

Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver. [Single cell RNA Seq]

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Osteopontin expression identifies a subset of recruited macrophages distinct from Kupffer cells in the fatty liver. [Bulk RNA Seq]

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Transcriptome and epigenome analysis of DIAMOND mice

Project description:Transcriptome and epigenome analysis of DIAMOND mice

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Spatial proteogenomics reveals distinct and evolutionarily-conserved hepatic macrophage niches (spatial)

Project description:Analysis of CITE-seq data , Nuclei RNA-seq data and single cell RNA-seq data on CD45+ and CD45- cells isolated from the livers of mice fed a standard diet (SD) or western diet (WD; fat, cholesterol and sugar), from healthy and steatotic human livers, from hamster liver, pig liver, chicken liver, monkey liver and zebrafish liver. We also performed Spatial Transcriptomics analysis on heatlhy mouse livers, NAFLD mouse livers, healthy human livers and steatotic human livers.

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Effect of damaging mutations in LXRalpha on the liver transcriptome

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Hepatic transcriptome profiling of liver-specific Xbp1 knockout mice fed a high fat diet

Project description:Xbp1 is an important regulator of unfolded protein response and lipid metabolism. Its dyregulation has been associcated in human NASH. Feeding a high fat diet with fructose/sucrose to mice causes progressive, fibrosing steatohepatitis. This study is to use RNA-Seq to identify differentially expressed genes in hepatic Xbp1 deficient mice livers fed with a high fat diet compared to controls. Hepatic Xbp1 deficient mice or flox controls were fed either regular chow or a high fat diet (n=4). Samples from each cohort were pooled into two replicates.

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Gene expression altered by high-fructose diet feeding and Chrebp deficiency

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Gene expression changes in Ahnak knockout mice

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