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Effect of damaging mutations in LXRalpha on the liver transcriptome

ABSTRACT: Damaging mutations in LXRalpha are associated with hepatotoxicity. We generated mice homozygous for a dominant-negative mutation in LXRalpha (LXRalpha-W441R) and discovered they develop severe liver injury when fed a Western diet, though knockout mice develop little to no liver injury. To examine this in further detail, we performed Bulk RNA-seq of livers from LXRalpha knockout and LXRalpha p.W441R knockin mice after 8 weeks of western diet (TD.88137).

ORGANISM(S): Mus musculus

PROVIDER: GSE273156 | GEO | 2024/07/31

REPOSITORIES: GEO

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