Transcriptomics

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Bone marrow transcriptomal differences between wild type, Fancc-deficient, Fancg-deficient, and doubly deficient (Fancc/Fancg) mice.


ABSTRACT: Seeking to challenge the current dogma that the nuclear core-complex proteins function in an entirely epistatic manner, Dr. Clapp's group developed a new double-knockout mouse nullizygous for Fancc and Fancg. Because the hematopoietic phenotype was more severe than single knockout mice, we reasoned that transcriptomal differences would exist and lead to the identification of molecular defects unique to each FA gene.

ORGANISM(S): Mus musculus

PROVIDER: GSE22094 | GEO | 2010/07/01

SECONDARY ACCESSION(S): PRJNA128831

REPOSITORIES: GEO

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