Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: D Clapp
PROVIDER: E-GEOD-22094 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pulliam-Leath Anna C AC Ciccone Samantha L SL Nalepa Grzegorz G Li Xiaxin X Si Yue Y Miravalle Leticia L Smith Danielle D Yuan Jin J Li Jingling J Anur Praveen P Orazi Attilio A Vance Gail H GH Yang Feng-Chun FC Hanenberg Helmut H Bagby Grover C GC Clapp D Wade DW
Blood 20100706 16
Fanconi anemia (FA) is an inherited chromosomal instability syndrome characterized by bone marrow failure, myelodysplasia (MDS), and acute myeloid leukemia (AML). Eight FA proteins associate in a nuclear core complex to monoubiquitinate FANCD2/FANCI in response to DNA damage. Additional functions have been described for some of the core complex proteins; however, in vivo genetic proof has been lacking. Here we show that double-mutant Fancc(-/-);Fancg(-/-) mice develop spontaneous hematologic seq ...[more]