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Systemic Hypoxemia Induces Cardiomyocyte Hypertrophy and Right Ventricular Specific Induction of Proliferation

ABSTRACT: A recent study suggests that systemic hypoxemia in adult male mice can induce cardiac myocytes to proliferate. The goal of the present experiments was to confirm these results, provide new insights on the mechanisms that induce adult cardiomyocyte cell cycle re-entry, and to determine if hypoxemia also induces cardiomyocyte proliferation in female mice. We also analyzed gene expression using data obtained from RNAseq of ventricular heart tissue from male and female mice subjected to either normoxia or hypoxia.

ORGANISM(S): Mus musculus

PROVIDER: GSE221168 | GEO | 2023/02/15

REPOSITORIES: GEO

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