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Transcription profiling of rat neonatal ventricular myocytes plated in fibronectin reveals fibronectin induced cardiac myocyte hypertrophy

ABSTRACT: Gene expression changes in neonatal rat ventricular myocytes plated in fibronectin (2 samples) or uncoated plates (2 samples).

ORGANISM(S): Rattus norvegicus

SUBMITTER: Jorge Sepulveda

PROVIDER: E-GEOD-1055 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression changes associated with fibronectin-induced cardiac myocyte hypertrophy.

Chen Hua H Huang Xueyin N XN Stewart Alexandre F R AF Sepulveda Jorge L JL

Physiological genomics 20040811 3

Fibronectin (FN) is an extracellular matrix protein that binds to integrin receptors and couples cardiac myocytes to the basal lamina. Cardiac FN expression is elevated in models of pressure overload, and FN causes cultured cardiac myocytes to hypertrophy by a mechanism that has not been characterized in detail. In this study, we analyzed the gene expression changes induced by FN in purified rat neonatal ventricular myocytes using the Affymetrix RAE230A microarray, to understand how FN affects g ...[more]

PMID: 15306692

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