Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE221181 | GEO | 2023/01/06

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 1

Project description:Tumor cell repopulation represents a critical factor in the failure of radiotherapy. Analogous to the concept of “drug-tolerant persistence (DTP)” in stress of chemo- or targeted therapy, here, we show that cancer cells enter a “radiation-tolerant persistence (RTP)” to survive radiotherapy and repopulate tumor. These RTP cells exhibit a distinct phenotype characterized by enlargement of cell sizes and nucleus, complex karyotype, cell cycle arrest and engagement of quiescence. A fraction of RTPs unexpectedly give birth to mitotic-competent progeny cells via a viral budding-mimicking cell division. To gain insight into the molecular mechanisms how RTPs generating progenies and repopulating tumors, we applied single cell SMART RNA-sequencing and 10x RNA-sequencing to different status of human colorectal cancer cells HCT116 before and exposed to irradiation. For the first time, we profiled two transitional transcriptional waves throughout budding process and characterized two gene panels associated with budding of RTPs, illustrating the therapeutic potential for blocking tumor repopulation after radiation.

2023-01-06 | GSE221180 | GEO

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 2

2023-01-06 | GSE221171 | GEO

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor

Project description:Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor

| PRJNA913157 | ENA

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 1

Project description:Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 1

| PRJNA913155 | ENA

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 2

Project description:Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 2

| PRJNA913154 | ENA

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-04-12 | GSE227797 | GEO

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-12-01 | GSE211149 | GEO

Tumor cells that survive oncogenic pathway inhibition exhibit cellular dormancy

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-07-24 | GSE60611 | GEO

Epigenetics of lactose intolerance and lactase persistence

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-03-25 | E-GEOD-69979 | biostudies-arrayexpress

Glut1-dependent aging of tumor-associated neutrophils dictates tumor support and sensitivity to radiotherapy.

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-03-18 | GSE140159 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data