Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 2

ABSTRACT: Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 2

PROVIDER: PRJNA913154 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor

Project description:Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor

| PRJNA913157 | ENA

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 1

Project description:Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 1

| PRJNA913155 | ENA

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 1

Project description:Tumor cell repopulation represents a critical factor in the failure of radiotherapy. Analogous to the concept of “drug-tolerant persistence (DTP)” in stress of chemo- or targeted therapy, here, we show that cancer cells enter a “radiation-tolerant persistence (RTP)” to survive radiotherapy and repopulate tumor. These RTP cells exhibit a distinct phenotype characterized by enlargement of cell sizes and nucleus, complex karyotype, cell cycle arrest and engagement of quiescence. A fraction of RTPs unexpectedly give birth to mitotic-competent progeny cells via a viral budding-mimicking cell division. To gain insight into the molecular mechanisms how RTPs generating progenies and repopulating tumors, we applied single cell SMART RNA-sequencing and 10x RNA-sequencing to different status of human colorectal cancer cells HCT116 before and exposed to irradiation. For the first time, we profiled two transitional transcriptional waves throughout budding process and characterized two gene panels associated with budding of RTPs, illustrating the therapeutic potential for blocking tumor repopulation after radiation.

2023-01-06 | GSE221180 | GEO

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor 2

2023-01-06 | GSE221171 | GEO

Cancer cells enter an adaptive persistence to survive radiotherapy and repopulate tumor

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-06 | GSE221181 | GEO

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy [ATAC-Seq]

Project description:This study examines the reorganization of transcriptionally active chromatin that underlies the adaptive response of glioblastoma cells to radiotherapy.

2023-12-01 | GSE211148 | GEO

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy [ChIP-Seq]

Project description:This study examines the reorganization of transcriptionally active chromatin that underlies the adaptive response of glioblastoma cells to radiotherapy.

2023-12-01 | GSE211147 | GEO

Colorectal cancer cells possess an equipotent capacity to enter a reversible diapause-like state to survive chemotherapy

Project description:Colorectal cancer cells possess an equipotent capacity to enter a reversible diapause-like state to survive chemotherapy

| PRJNA606811 | ENA

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

Project description:Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

| PRJNA869094 | ENA

Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

Project description:Rapid PTEFb-dependent transcriptional reorganization underpins the glioma adaptive response to radiotherapy

| PRJNA947077 | ENA