Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [ChIP-seq]

ABSTRACT: To understand the impact of Bcl11b N440K variant on the DNA recognition by Bcl11b, we performed ChIP-seq of Bcl11b with Bcl11b+/+ and Bcl11b+/N440K thymocytes.

ORGANISM(S): Mus musculus

PROVIDER: GSE221763 | GEO | 2024/09/27

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development.

Project description:To understand the impact of Bcl11b N440K variant on the DNA recognition by TCF1, we performed ChIP-seq of Bcl11b with Bcl11b+/+ and Bcl11b+/N440K thymocytes.

2024-09-27 | GSE263016 | GEO

A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [RNA-seq]

Project description:CD24-TCRb- thymocytes emerged the thymus of mice carrying Bcl11b N440K variant and Tcf7 deficient mice. To investigate the feature of these cells, we performed RNA-seq.

2024-09-27 | GSE221764 | GEO

A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-09-27 | GSE221765 | GEO

A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development.

Project description:A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development.

| PRJNA1095454 | ENA

A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development

Project description:A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development

| PRJNA915975 | ENA

A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [ChIP-seq]

Project description:A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [ChIP-seq]

| PRJNA915974 | ENA

A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [RNA-seq]

Project description:A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [RNA-seq]

| PRJNA915977 | ENA

Expression profile of bcl11b-/- preselected DP thymocytes

Project description:Review on the role of Bcl11b in thymus and periphery and impact on diseases RNA was extracted from DP thymocytes of bcl11bf/fCd4cre/tcra-/- and tcra-/- mice. Tcra-/- mice only have preselected DP thymocytes. Such mice were used to determine the role of Bcl11b before selection, considering the defective positive selection in bcl11bf/fcd4cre mice. RNA was isolated and submitted for library generation and microarray analysis to determine expression profile of bcl11b-/- preselected DP thymocytes.

2014-04-12 | E-GEOD-56714 | biostudies-arrayexpress

Bcl11b hypomorphic mutant thymocytes

Project description:Bcl11b hypomorphic mutant thymocytes

| PRJNA356604 | ENA

Tcf1 regulates T lymphocyte lineage fidelity through its target genes Gata3 and Bcl11b

Project description:T cell factor 1 (Tcf1) is the first T cell‒specific protein induced in multipotent progenitors following Notch signaling in the thymus, leading to the activation of two major target genes, Gata3 and Bcl11b. Tcf1 deficiency results in partial arrests in T cell development high apoptosis, and increased development of B cells and myeloid cells. Phenotypically, fully T cell‒committed, Tcf1-deficient thymocytes have promiscuous gene expression, an altered epigenetic profile and can de-differentiate into more immature thymocytes and non-T cells. Expressing Bcl11b in Tcf1-deficient cells rescues T cell development, but does not strongly suppress the development of non-T cells; in contrast, expressing Gata3 suppresses the development of non-T cells, but does not rescue T cell development. Thus, T cell development is controlled by a minimal transcription factor network involving Notch signaling, Tcf1, and the subsequent division of labor between Bcl11b and Gata3, thereby ensuring a properly regulated T cell gene expression program

2019-08-28 | GSE119469 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data