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A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [RNA-seq]

ABSTRACT: CD24-TCRb- thymocytes emerged the thymus of mice carrying Bcl11b N440K variant and Tcf7 deficient mice. To investigate the feature of these cells, we performed RNA-seq.

ORGANISM(S): Mus musculus

PROVIDER: GSE221764 | GEO | 2024/09/27

REPOSITORIES: GEO

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A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development.

Project description:To understand the impact of Bcl11b N440K variant on the DNA recognition by TCF1, we performed ChIP-seq of Bcl11b with Bcl11b+/+ and Bcl11b+/N440K thymocytes.

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A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development [ChIP-seq]

Project description:To understand the impact of Bcl11b N440K variant on the DNA recognition by Bcl11b, we performed ChIP-seq of Bcl11b with Bcl11b+/+ and Bcl11b+/N440K thymocytes.

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Tcf1 regulates T lymphocyte lineage fidelity through its target genes Gata3 and Bcl11b

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A mutant Bcl11b protein interferes with Bcl11a function during T lymphocyte and neuronal development

Project description:This SuperSeries is composed of the SubSeries listed below.

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