Oncostatin M signaling drives cancer-associated skeletal muscle wasting
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ABSTRACT: Investigating muscle wasting in a murine model of cancer cachexia, we identified Oncostatin M (OSM) as a potential mediator of inflammatory responses in skeletal muscle. OSM is a member of the IL-6 family of cytokines and has crucial functions in cell growth, differentiation, and inflammation. Our results demonstrate that OSM induces muscle atrophy. To understand if its effect is specific or it is a general effect of IL6 family cytokines, primary myotubes were treated with OSM, IL6 and LIF for 48hrs. Our findings showed that OSM potently induces muscle wasting in differentiated myotubes.
ORGANISM(S): Mus musculus
PROVIDER: GSE222208 | GEO | 2024/03/21
REPOSITORIES: GEO
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