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RNA-seq of myelinating oligodendrocytes in Lmna wt and knockout mice

ABSTRACT: We showed that the composition of the nucler lamina changes with the differentiation state of oligodendrocyte lineage cells, with Lamin B highly expressed in progenitor cells and Lamin A highly expressed in mature oligodendrocytes. The genetic deletion of Lmna in oligodendrocytes results in the onset of a progressive motor phenotype in adult mice. We performed RNA-Seq in myelinating oligodendrocytes expressing the reporter myelin marker NDRG1-EGFP ( Marechal et al., 2021) in the presence or absence of LMNA. The goal is to identify the transcriptome profile in mice LMNA ablated cells compared to the controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE222574 | GEO | 2023/06/21

REPOSITORIES: GEO

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ATAC-seq in myelinating oligodendrocytes from wt and Lmna knockout mice

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