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Hypomethylating agents sensitize diffuse large B-cell lymphoma to venetoclax

ABSTRACT: We established acquired venetoclax resistant OCI-LY1R cell line by treating venetoclax sensitive parental OCI-Ly1 cell line with increasing doses of venetoclax up till 1µM. Parental OCI-Ly1 and venetoiclax-resistant OCI-Ly1R cells were treated with vehicle control or decitabine at 1uM for 3 days. We found that decitabine differantially regulated gene expression in venetoclax sensitive and resistant cells. With gene set enrichment analysis, we identified two pathways that were deregulated by decitabine in both cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE223598 | GEO | 2023/07/25

REPOSITORIES: GEO

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