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Effect of BFD2 (TGME49_311100) deletion on gene expression in Toxoplasma gondii

ABSTRACT: The acute-to-chronic stage transition in Toxoplasma gondii involes a global restructuring of the parasite transcriptome and is induced under alkaline stress. We found that parasites lacking the RNA-binding protein BFD2 are unable to produce chronic forms, consistent with a block in this develomental program. To understand how BFD2 facilitates chronic-stage transcriptional reprogramming in T. gondii, we profiled the transcriptomes of both 'wildtype' and BFD2-knockout parasites under alkaline-stressed and standard culture conditions

ORGANISM(S): Toxoplasma gondii

PROVIDER: GSE223869 | GEO | 2023/03/31

REPOSITORIES: GEO

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