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Insights into the evolution of dermal armour: osteoderms in a mammal, the spiny mouse

ABSTRACT: The goals of this study are to compare NGS-derived transcriptomes (RNA-Seq) derived from skin sampled from the distal and the proximal regions. Using Acomys cahirinus we describe the structure and development of osteoderms in the tail which develop in a proximal to distal and dorsal to ventral sequence over a 6-week period postnatally. We use RNA sequencing to identify which gene regulatory networks are involved in their development which together suggests a deep molecular homology exists in the mammalian dermis which can be activated at any time in evolution.

ORGANISM(S): Acomys cahirinus

PROVIDER: GSE224007 | GEO | 2023/01/30

REPOSITORIES: GEO

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An ERK-dependent molecular switch antagonizes fibrosis and promotes regeneration in spiny mice (Acomys)

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Smart RNA sequencing Facilitates Quantitative Analysis of dermal CD4+ Trm cells between SLE and NC.

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