Transcriptomics

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Cyclin B1 deficiency in renal tubular epithelial cells promotes kidney ageing and fibrosis in mice


ABSTRACT: After severe renal injury, renal tubular epithelial cells (TECs) will be arrested in G2/M phase, and the arrested cells will be aging, showing senescence related secretory phenotype (SASP), which mediates renal fibrosis by secreting fibrogenic cytokines. Cyclin B1 is an important protein that promotes G2/M phase transition of cell cycle. Its role in renal fibrosis mediated by G2/M arrest of TECs is unknown. The aim of this study was to investigate the role of cyclin B1 in renal fibrosis induced by TECs G2/M arrest and its mechanism

ORGANISM(S): Mus musculus

PROVIDER: GSE224039 | GEO | 2024/01/01

REPOSITORIES: GEO

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