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Effect of different genes expression with the development of peri-implantitis

ABSTRACT: To identify key lncRNAs and mRNAs and investigate the possible mechanisms associated with peri-implantitis, whole-transcriptome sequencing was performed based on 2 inflammatory tissues of peri-implantitis and 2 gingival tissues of healthy individuals

ORGANISM(S): Homo sapiens

PROVIDER: GSE224044 | GEO | 2024/02/01

REPOSITORIES: GEO

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Comparative transcriptome analysis of periodontitis and peri-implantitis in the same subject

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Comparison of lncRNA and mRNA expression levels in peri-implantitis and periodontitis

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Comparison of mRNA expression levels in peri-implantitis and periodontitis within the same host environment

Project description:Purpose: The aim of this study was to explore whether differences exist and to what an extent of the immune-mediated inflammatory reactions between periodontitis and peri-implantitis at the transcriptional level in the same susceptible host. Methods: Ligature-induced experimental peri-implantitis and periodontitis in the same mice were established. Gingival tissues of healthy, periodontitis and peri-implantitis sites from the same oral cavity were collected and used for RNA-sequencing. Differentially expressed genes (DEGs) were screened between periodontitis/peri-implantitis sites and healthy sites. The enrichment analysis of DEGs were analyzed. Comprehensive immune landscape was annotated by seq-ImmuCC. Results: The results showed that 137 and 353 up-regulated DEGs as well as and 670 and 174 down-regulated DEGs were specifically expressed periodontitis/peri-implantitis group compared to the healthy control group, respectively. The pathways of complement and coagulation cascade and osteoclast differentiation were dominating in the peri-implantitis sites. Moreover, peri-implantitis sites exhibited elevated macrophage proportions and relatively enriched macrophage activation and bone loss compared with periodontitis. Conclusions: Results indicated that peri-implantitis and periodontitis exhibited significantly distinct transcriptional signatures. Additionally, the study suggests that the interplay between macrophages and bone resorption are comparatively more active in peri-implantitis compared with periodontitis. These biological processes may be factors contributing to the pathogenesis of peri-implantitis being distinct from that of periodontitis.

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Scgb1a1, Lpo and Gbp2 is Characteristically Expressed in Rat Peri-Implant Epithelium.

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