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Effect of pharmacological BCL-2 inhibition with venetoclax on T cell homeostasis

ABSTRACT: Venetoclax, a BCL-2 specific inhibitor, has been show to confer transcriptional changes in T cell populations. In order to elucidate how these changes may be occuring, we sought to investigate whether there are epigenetic alterations that may offer a potential explanation. To begin to answer this question, we conducted ATAC-sequencing on Treg cells isolated from FOXP3-IRES-GFP mice treated for 14 days with 50mg/kg of venetoclax and assessed for global accessibility changes.

ORGANISM(S): Mus musculus

PROVIDER: GSE224080 | GEO | 2023/09/01

REPOSITORIES: GEO

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| S-EPMC10192431 | biostudies-literature

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