Proteomics

Dataset Information

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IMPRINTS-CETSA Venetoclax in Kasumi-1 cells, 6h incubation

ABSTRACT: IMPRINTS-CETSA data acquisition of Kasumi-1 cells treated with Vehicle (DMSO), Venetoclax, Decitabine, Azacitidine and Azacitidine+Venetoclax using TMT 16 plex.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Marc-Antoine Gerault  

LAB HEAD: Pär Nordlund

PROVIDER: PXD056189 | Pride | 2024-10-23

REPOSITORIES: Pride

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Dataset's files

Source:
Action DRS
Kasumi_Venetoclax6h_37C_10.raw Raw
Kasumi_Venetoclax_1h_37C_PeptideGroups.txt Txt
Kasumi_Venetoclax_1h_47C_PeptideGroups.txt Txt
Kasumi_Venetoclax_1h_50C_PeptideGroups.txt Txt
Kasumi_Venetoclax_1h_52C_PeptideGroups.txt Txt
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Publications

Proteome-wide CETSA reveals diverse apoptosis-inducing mechanisms converging on an initial apoptosis effector stage at the nuclear periphery.

Ramos Anderson Daniel AD   Liang Ying Yu YY   Surova Olga O   Bacanu Smaranda S   Gerault Marc-Antoine MA   Mandal Tamoghna T   Ceder Sophia S   Langebäck Anette A   Österroos Albin A   Ward George A GA   Bergh Jonas J   Wiman Klas G KG   Lehmann Sören S   Prabhu Nayana N   Lööf Sara S   Nordlund Pär P  

Cell reports 20241003 10

Cellular phenotypes of apoptosis, as well as the activation of apoptosis caspase cascades, are well described. However, sequences and locations of early biochemical effector events after apoptosis initiation are still only partly understood. Here, we use integrated modulation of protein interaction states-cellular thermal shift assay (IMPRINTS-CETSA) to dissect the cellular biochemistry of early stages of apoptosis at the systems level. Using 5 families of cancer drugs and a new CETSA-based meth  ...[more]

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