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GMP-MoPs can be classified as an independent cell type that differentiate from GMPs through proNeu1 without going through the MDP-cMoP pathway [scRNA-seq]

ABSTRACT: This analysis was performed to track the bifurcation of differentiation path of neutrophil lineage at the proNeu1 stage, giving rise to either prNeu2 or GMP-MoPs.

ORGANISM(S): Mus musculus

PROVIDER: GSE224701 | GEO | 2023/03/13

REPOSITORIES: GEO

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GMP-MoPs can be classified as an independent cell type that differentiate from GMPs through proNeu1 without going through the MDP-cMoP pathway [scRNA-seq]

Project description:GMP-MoPs can be classified as an independent cell type that differentiate from GMPs through proNeu1 without going through the MDP-cMoP pathway [scRNA-seq]

| PRJNA934487 | ENA

The chromatin structures of GMP-MoPs are shifted toward ones that favors an aberrant differentiation pathway generating GMP-MoPs from proNeu1 [ATAC-seq]

Project description:To assess the chromatin structure of GMP-MoPs, we performed assay for transposase-accessible chromatin sequencing (ATAC-seq) analysis of MDP, cMoP, GMP, proNeu1, proNeu2, and GMP-MoP of mouse BM. The PCA of ATAC-seq positioned GMP-MoPs between proNeu1 and cMoPs.

2023-03-13 | GSE224100 | GEO

GMP-MoPs display mixed gene expression profiles of both neutrophil and monocyte progenitors [RNAseq mouse]

Project description:This analysis was performed to visualize the distinction between GMP-MoPs and other monocyte and neutrophil progenitors. Transcription factors differentially expressed between GMP-MoPs and cMoPs were selected.

2023-03-13 | GSE224102 | GEO

Inflammation rapidly recruits mammalian GMP and MDP from bone marrow into regional lymphatics.

Project description:Innate immune cellular effectors are actively consumed during systemic inflammation, but the systemic traffic and the mechanisms that support their replenishment remain unknown. Here, we demonstrate that acute systemic inflammation induces the emergent activation of a previously unrecognized system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors, but not other progenitors or stem cells, from bone marrow (BM) to regional lymphatic capillaries. The progenitor traffic to the systemic lymphatic circulation is mediated by Ccl19/Ccr7 and is NF-κB independent, Traf6/IκB-kinase/SNAP23 activation dependent, and is responsible for the secretion of pre-stored Ccl19 by a subpopulation of CD205+/CD172a+ conventional dendritic cells type 2 and upregulation of BM myeloid progenitor Ccr7 signaling. Mature myeloid Traf6 signaling is anti-inflammatory and necessary for lymph node myeloid cell development. This report unveils the existence and the mechanistic basis of a very early direct traffic of myeloid progenitors from BM to lymphatics during inflammation.

| S-EPMC8137144 | biostudies-literature

Expression data of GMP and MDP from wild-type and Trib1-/- mice

Project description:Trib1 is critical for some myeloid cell differentiation. Therefore we used microarrays to investigate gene expression profiles in wild-type and Trib1-/- progenitor of myeloid cells. Progenitor cells, such as GMP and MDP, obtained from wild-type and Trib1-/- mice were sorted, followed by RNA extraction. Then hybridization on affymetrix microarrays was performed.

2013-01-18 | E-GEOD-43563 | biostudies-arrayexpress

Murine GMP- and MDP-derived classical monocytes have distinct functions and fates.

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-05-04 | GSE262369 | GEO

Expression data of GMP and MDP from wild-type and Trib1-/- mice

2013-01-18 | GSE43563 | GEO

A proteomic approach to differentiate histologically classified stable and unstable plaques from human carotid arteries.

Project description:ObjectivesBy using proteomics we isolated and identified proteins that were expressed/retained in stable and unstable human carotid artery atherosclerotic plaques.MethodsThe criteria for plaque instability were the presence of a thin fibrous cap or fissured cap covering the foamy or necrotic core, and the presence of overt, hemorrhagic, ulcerated or thrombotic plaques. Proteins were extracted from finely minced endarterectomy specimens (19 stable and 29 unstable plaques) and separated by two-dimensional gel electrophoresis. Coomassie Blue-stained gels were analysed using PD-Quest software.ResultsA total of 57 distinct spots corresponding to 33 different proteins were identified by matrix assisted laser desorption/ionization mass spectrometry using the NCBI database. Most of the spots were present in both types of extracts, although significantly (p<0.05) differing in abundance between them. Compared to stable plaque, unstable ones showed reduced abundance of: protective enzymes SOD3 and GST, small heat shock proteins HSP27 and HSP20, annexin A10, and Rho GDI. In unstable plaques the more abundant proteins were: ferritin light subunit, SOD 2 and fibrinogen fragment D. For fibrinogen fragment D, the increased levels in unstable versus stable plaques was confirmed by Western blot analysis.ConclusionsSince many of the differentially expressed proteins are known to have a functional role in inflammation and oxidative stress, we speculate that they may be involved in events relating to plaque stability.

| S-EPMC2659534 | biostudies-literature

The chromatin structures of GMP-MoPs are shifted toward ones that favors an aberrant differentiation pathway generating GMP-MoPs from proNeu1 [ATAC-seq]

Project description:The chromatin structures of GMP-MoPs are shifted toward ones that favors an aberrant differentiation pathway generating GMP-MoPs from proNeu1 [ATAC-seq]

| PRJNA929906 | ENA

Murine GMP- and MDP-derived classical monocytes have distinct functions and fates [dataset 1]

Project description:Monocytes are ephemeral myeloid immune cells that arise from adult hematopoiesis and circulate in the blood. They comprise two main subsets, in mice defined as classical and non-classical monocytes (CM, NCM). Recent fate mapping and transcriptomic analyses revealed that CM themselves are heterogeneous. Here, we report surface markers that allow segregation of murine GMP- and MDP-derived CM, as well as their functional characterization, including fate definition following adoptive cell transfer. GMP-Mo and MDP- Mo gave equal rise to homeostatic CM progeny, such as blood NCM and gut macrophages; the cells however differentially seeded selected other tissues, including the dura mater and lung. Specifically, GMP-Mo and MDP-Mo gave rise to distinct interstitial lung macrophages, linking CM dichotomy to previously reported pulmonary macrophage heterogeneity. Collectively, we provide evidence for the existence of two functionally distinct CM subsets in the mouse, which differentially contribute to peripheral tissue macrophage populations in homeostasis and following challenge.

2024-05-04 | GSE261003 | GEO

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