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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE225036 | GEO | 2023/03/01

REPOSITORIES: GEO

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

Project description:The clonal selection theory describes the key features of adaptive immune responses of B and T cells. For αβ T cells and B cells antigen recognition and selection principles are known at a detailed molecular level. The precise role of the antigen receptor in γδ T cells remains less well understood. To better understand the role of the γδ T cell receptor (TCR), in particular its specificity for thymic selection of γδ T cells and for γδ T cell biology in general, we generated a novel orthotopic TCRδ transgenic mouse model. We demonstrate a multi-layered functionality of γδ TCRs and diverse roles of CDR3δ-mediated selection during γδ T cell development. Whereas epithelial populations using Vγ5 or Vγ7 chains are affected to only minor extend in their biology in the presence of a single TCRδ chain, pairing with Vγ1 positively selects subpopulations of γδ T cells with distinct programs in several organs, thereby distorting the repertoire. In conclusion, our data support dictation of developmental tropism together with adaptive-like recognition principles in a single antigen receptor.

2023-02-24 | GSE225874 | GEO

A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (VDJ)

2023-03-01 | GSE225035 | GEO

A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (NGS)

2023-03-01 | GSE225034 | GEO

A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (GEX)

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

Project description:A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

Project description:A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (GEX)

Project description:A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (GEX)

| PRJNA934585 | ENA

A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (NGS)

Project description:A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (NGS)

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (VDJ)

Project description:A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (VDJ)

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Development of a new monoclonal antibody specific to mouse V?6 chain.

Project description:There are seven V? gene segments in the TCR ? chain loci of mice. We developed monoclonal antibodies (mAbs) specific to the V?6 chain (Heilig & Tonegawa nomenclature). By immunizing V?4/6 KO mice with complementarity-determining region peptides in V?6 chains, we generated three hybridomas. These hybridomas produced mAbs capable of cell surface staining of V?6/V?1 gene-transfected T-cell line lacking TCR as well as of V?1- V?4- V?5- V?7- ?? T cells and the CD3high TCR?int ?? T cells in various organs. The location of V?6+ ?? T cells, which peaked in the newborn thymus, was associated with mTEC. In vivo administration of clone 1C10-1F7 mAb impaired protection against Klebsiella pneumoniae infection but ameliorated psoriasis-like dermatitis induced by imiquimod treatment. These new mAbs are useful to elucidate the development, location, and functions of V?6 ?? T cells in mice.

| S-EPMC6504751 | biostudies-literature

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