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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

ABSTRACT: A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

PROVIDER: PRJNA933595 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23399514_1.fastq.gz	Fastqsanger.gz
	SRR23399514_2.fastq.gz	Fastqsanger.gz
	SRR23399515_1.fastq.gz	Fastqsanger.gz
	SRR23399515_2.fastq.gz	Fastqsanger.gz
	SRR23399516_1.fastq.gz	Fastqsanger.gz

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (NGS)

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Project description:A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (VDJ)

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

Project description:The clonal selection theory describes the key features of adaptive immune responses of B and T cells. For αβ T cells and B cells antigen recognition and selection principles are known at a detailed molecular level. The precise role of the antigen receptor in γδ T cells remains less well understood. To better understand the role of the γδ T cell receptor (TCR), in particular its specificity for thymic selection of γδ T cells and for γδ T cell biology in general, we generated a novel orthotopic TCRδ transgenic mouse model. We demonstrate a multi-layered functionality of γδ TCRs and diverse roles of CDR3δ-mediated selection during γδ T cell development. Whereas epithelial populations using Vγ5 or Vγ7 chains are affected to only minor extend in their biology in the presence of a single TCRδ chain, pairing with Vγ1 positively selects subpopulations of γδ T cells with distinct programs in several organs, thereby distorting the repertoire. In conclusion, our data support dictation of developmental tropism together with adaptive-like recognition principles in a single antigen receptor.

2023-02-24 | GSE225874 | GEO

A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages (VDJ)

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2023-03-01 | GSE225034 | GEO

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A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-03-01 | GSE225036 | GEO

Expression data from mouse small intestinal γδ intraepithelial lymphocytes

Project description:The mammalian gastrointestinal tract harbors thousands of bacterial species that include symbionts as well as potential pathogens. The immune responses that limit access of these bacteria to underlying tissue remain poorly defined. In this study, we used microarrays to uncover the transcriptional responses that occur in small intestinal γδ intraepithelial lymphocytes following bacterial challenge. γδ intraepithelial lymphocytes (γδ IEL) were isolated by flow cytometry from the small intestines of germ-free mice, or from age- and sex-matched conventionally-raised counterparts. We extracted RNAs from these purified γδ IEL for analysis on Affymetrix DNA microarrays. The mice were all >8 weeks in age, and each sample represents a pool of RNAs from 5-8 mice.

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