Genomics

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Tissue-specific non-heritable influence drive uterine immune system variation (ATAC-seq)


ABSTRACT: Human twin studies have revealed the combined contribution of heritable and non-heritable (environmental) factors in shaping peripheral blood immune system variability. However, the heterogeneity within tissue immune compartments and the contribution of tissue-specific external factors remain unexplored. The human uterus is a tissue under constant regeneration exposed to distinct environmental factors. To assess uterine immune system variation, we have performed a transcriptomic and epigenetic analysis of uterine and peripheral blood immune cells in monozygotic twins and longitudinal samples in relation to heritable versus non-heritable factors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE225040 | GEO | 2024/04/12

REPOSITORIES: GEO

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