Dataset Information

Quantitative variability of 342 plasma proteins in a human twin population

ABSTRACT: The human plasma proteome is clinically highly significant and has been studied extensively because it is thought that its molecular makeup provides a window into the health state of an individual. However, neither the quantitative variability of the plasma proteome nor the origins of the variation are known. To determine the relative contributions of heritability, environmental and longitudinal factors to plasma proteome variability we systematically decomposed the biological variance of 1904 peptides defining 342 unique plasma protein profiles from 232 plasma samples that were collected with 2-7 year intervals from monozygotic (MZ) and dizygotic (DZ) twins. The data were collected via SWATH mass spectrometry (SWATH-MS), an emerging technology characterized by high degree of reproducibility and quantitative accuracy. The data indicate abundance variability is an important feature for different proteins among population, that the abundances of about 20% of plasma protein are considerably heritable, and that the degrees of genetic control and aging effects vary across specific biological processes. Moreover, we identified 13 cis- SNPs significantly influencing the abundance level of specific plasma proteins. These results substantially extend the understanding of the impact of heritability on the human proteomic dynamics and therefore have implications for the effective design of plasma-based biomarker studies.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

SUBMITTER: Yansheng Liu

LAB HEAD: Ruedi Aebersold

PROVIDER: PXD001064 | Pride | 2015-01-05

REPOSITORIES: Pride

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Dataset's files

Source:

			Action	DRS
	OpenSWATHResult_feature_alignment_requant.tsv	Tabular
	SWATHsampleInformation_updated201501.txt	Txt
	SkylineFilesVisualizaion.zip	Other
	UK_plasma_2013522_Noiso_Uniprotsemi_p085PlusPHL2Plasm_20131219.traML	Other
	interact.pep.xml	Pepxml

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Publications

Quantitative variability of 342 plasma proteins in a human twin population.

Liu Yansheng Y Buil Alfonso A Collins Ben C BC Gillet Ludovic C J LC Blum Lorenz C LC Cheng Lin-Yang LY Vitek Olga O Mouritsen Jeppe J Lachance Genevieve G Spector Tim D TD Dermitzakis Emmanouil T ET Aebersold Ruedi R

Molecular systems biology 20150204 1

The degree and the origins of quantitative variability of most human plasma proteins are largely unknown. Because the twin study design provides a natural opportunity to estimate the relative contribution of heritability and environment to different traits in human population, we applied here the highly accurate and reproducible SWATH mass spectrometry technique to quantify 1,904 peptides defining 342 unique plasma proteins in 232 plasma samples collected longitudinally from pairs of monozygotic ...[more]

PMID: 25652787

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