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Effect of LRP1 deletion in vascular mural cells and APOE gentotype on gene expression in mouse brains

ABSTRACT: To investigate the apoE isoform-dependent role of vascular mural cell (VMC)-LRP1, we generated VMC-specific LRP1 knockout mice (smLrp1-/-), followed by breeding these mice with either APOE3-targeted replacement (TR) or APOE4-TR mice We then performed gene expression profiling analysis using data obtained from RNA-seq of cortical samples from 4 different mouse models

ORGANISM(S): Mus musculus

PROVIDER: GSE225065 | GEO | 2023/05/12

REPOSITORIES: GEO

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