Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rs1663689 interchromosomally regulates ADGRG6 and modulates the malignant progression of lung cancer

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE225524 | GEO | 2023/05/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

rs1663689 interchromosomally regulates ADGRG6 and modulates the malignant progression of lung cancer

Project description:rs1663689 interchromosomally regulates ADGRG6 and modulates the malignant progression of lung cancer

| PRJNA936115 | ENA

LSD1 promotes castration-resistant prostate cancer progression

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-06-30 | E-GEOD-77763 | biostudies-arrayexpress

ARRB1 regulates prostate cancer cell metabolism

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-11-26 | E-GEOD-55616 | biostudies-arrayexpress

The pattern of genomic instability during bladder cancer progression

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2014-07-01 | E-GEOD-50668 | biostudies-arrayexpress

Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing transcription and splicing of tumorigenesis-related genes

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-07-01 | GSE234860 | GEO

The placental gene PEG10 promotes progression of neuroendocrine prostate cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-01-05 | E-GEOD-59986 | biostudies-arrayexpress

Non-coding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression

Project description:A previous genome-wide association study (GWAS) revealed an association of the non-coding SNP rs1663689 with susceptibility to lung cancer in the Chinese population. However, the underlying mechanism is unknown. In this study, using allele-specific 4C-seq in heterozygous lung cancer cells combined with epigenetic information from CRISPR/Cas9-edited cell lines, we show that the rs1663689 C/C variant represses expression of ADGRG6, a gene located on a separate chromosome, through an interchromosomal interaction of the rs1663689 bearing region with the ADGRG6 promoter. This reduces downstream cAMP-PKA signaling and subsequently tumor growth both in vitro and in xenograft models. Using patient-derived organoids, we show that rs1663689 T/T - but not C/C - bearing lung tumors are sensitive to the PKA inhibitor H89, potentially informing therapeutic strategies. Our study identifies a genetic variant-mediated interchromosomal interaction underlying ADGRG6 regulation and suggests that targeting the cAMP-PKA signaling pathway may be beneficial in lung cancer patients bearing the homozygous risk genotype at rs1663689.

| S-SCDT-10_15252-EMBR_202256212 | biostudies-other

ADAM9 Up-regulates N-Cadherin via MiR-218 Suppression in Lung Adenocarcinoma Cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-07-03 | E-GEOD-52051 | biostudies-arrayexpress

The MLL3/GRHL2 complex regulates early malignant transformation and anti-tumor immunity in squamous cancer

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-20 | GSE238119 | GEO

PI3K/AKT signaling regulates H3K4 methylation in breast cancer

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-06-14 | E-GEOD-80594 | biostudies-arrayexpress