Transcriptomics

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Multi-ancestry genetic analysis of gene regulation in coronary artery prioritizes disease risk loci


ABSTRACT: Genome-wide association studies (GWAS) have identified hundreds of genetic risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in coronary artery disease (CAD). However, non-European populations are underrepresented in GWAS and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporated local ancestry and haplotype information to identify quantitative trait loci (QTL) for gene expression and splicing in coronary arteries obtained from 138 ancestrally diverse Americans.

ORGANISM(S): Homo sapiens

PROVIDER: GSE225650 | GEO | 2023/11/14

REPOSITORIES: GEO

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