Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

A nucleosome switch primes Hepatitis B Virus infection

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens Hepatitis B virus

PROVIDER: GSE225716 | GEO | 2023/03/03

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

A nucleosome switch primes Hepatitis B Virus infection [Mnase-Seq]

Project description:Chronic hepatitis B virus (HBV) infection is an incurable global health threat capable of causing liver disease and hepatocellular carcinoma. During the genesis of infection, HBV establishes an independent chromosome, cccDNA, consisting of the circular viral genome and host histones. The first viral protein expressed, HBx, induces degradation of a host silencing factor to facilitate infection. However, the relationship between cccDNA’s chromatin and early HBx transcription state remains poorly understood. Using reconstituted viral chromosomes, we found that nucleosomes in cccDNA drive HBx transcription. We corroborated these findings in cells and further showed that chromatin destabilizing drugs inhibit viral transcription and antigen expression in hepatocytes. Our results shed new light on a long-standing paradox and represent a novel therapeutic avenue for the treatment of chronic HBV.

2023-03-03 | GSE225715 | GEO

A nucleosome switch primes Hepatitis B Virus infection [RNA-Seq]

2023-03-03 | GSE225714 | GEO

A nucleosome switch primes Hepatitis B Virus infection [ChIP-Seq]

Project description:Chronic hepatitis B virus (HBV) infection is an incurable global health threat responsible for causing liver disease and hepatocellular carcinoma. During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones. The viral X gene must be expressed immediately upon infection to induce degradation of the host silencing factor, Smc5/6. However, the relationship between cccDNA chromatinization and X gene transcription remains poorly understood. Establishing a reconstituted viral minichromosome platform, we found that nucleosome occupancy in cccDNA drives X transcription. We corroborated these findings in cells and further showed that the chromatin destabilizing molecule CBL137 inhibits X transcription and HBV infection in hepatocytes. Our results shed light on a long-standing paradox and represent a potential new therapeutic avenue for the treatment of chronic HBV infection.

2024-06-19 | GSE270130 | GEO

mRNA and miRNA analysis during hepatitis C virus infection

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-02-17 | E-GEOD-44370 | biostudies-arrayexpress

Hepatitis C virus functionally sequesters miR-122

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-01-06 | E-GEOD-64680 | biostudies-arrayexpress

mRNA and miRNA analysis during hepatitis C virus infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2013-02-17 | GSE44370 | GEO

Hepatitis B virus-mediated alterations to the primary hepatocyte transcriptome

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-01-20 | E-GEOD-68113 | biostudies-arrayexpress

microRNA and mRNA expression in human hepatitis C Virus liver biopsies

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series This dataset is part of the TransQST collection.

2010-03-08 | E-GEOD-15387 | biostudies-arrayexpress

Hepatitis C virus-induced expression profiling of Hepatic and non-hepatic cancer cell lines

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-07-10 | E-GEOD-70781 | biostudies-arrayexpress

An atlas of the human liver diurnal transcriptome and its perturbation by hepatitis C virus infection

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-08-02 | GSE200812 | GEO