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A nucleosome switch primes Hepatitis B Virus infection

ABSTRACT: A nucleosome switch primes Hepatitis B Virus infection

PROVIDER: PRJNA937206 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23575115_1.fastq.gz	Fastqsanger.gz
	SRR23575115_2.fastq.gz	Fastqsanger.gz
	SRR23575116_1.fastq.gz	Fastqsanger.gz
	SRR23575116_2.fastq.gz	Fastqsanger.gz
	SRR23575117_1.fastq.gz	Fastqsanger.gz

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Project description:Chronic hepatitis B virus (HBV) infection is an incurable global health threat responsible for causing liver disease and hepatocellular carcinoma. During the genesis of infection, HBV establishes an independent minichromosome consisting of the viral covalently closed circular DNA (cccDNA) genome and host histones. The viral X gene must be expressed immediately upon infection to induce degradation of the host silencing factor, Smc5/6. However, the relationship between cccDNA chromatinization and X gene transcription remains poorly understood. Establishing a reconstituted viral minichromosome platform, we found that nucleosome occupancy in cccDNA drives X transcription. We corroborated these findings in cells and further showed that the chromatin destabilizing molecule CBL137 inhibits X transcription and HBV infection in hepatocytes. Our results shed light on a long-standing paradox and represent a potential new therapeutic avenue for the treatment of chronic HBV infection.

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Project description:This SuperSeries is composed of the SubSeries listed below.

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Association Between Hepatitis C Infection and Renal Cell Carcinoma

Project description:The purpose of this study is to determine if there is an association between hepatitis C infection and kidney cancer. All patients who are diagnosed with kidney cancer and who will either have a biopsy or surgery will be offered to be tested for hepatitis C. The control group will be colon cancer patients. Both groups would be of recent diagnosis (6 months).

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