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Histone lactylation antagonizes Senescent via facilitating gene-expression reprogramming [CUT&Tag]

ABSTRACT: The hallmark of aging is a remarkable rearrangement of histone modifications, which reflect alterations in the cellular environment. Here, we show that histone lactylation, a novel histone modification that bridges metabolism and epigenetics, plays a crucial role in antagonizing Senescent. The level of histone lactylation is markedly decreased during Senescent but restored following anti-Senescent treatment such as physiological hypoxic conditions and the application of nicotinamide mononucleotide, a potent precursor for NAD+. We describe the genome-wide distribution profile and gene expression network of histone lactylation during Senescent, revealing that histone lactylation prevents the Senescent program by increasing the expression of anti-aging genes and activating related signaling pathways. Moreover, running exercise enhances the level of histone lactylation and reconstructs the cell composition of mouse skeletal muscle, leading to functional improvement. Our data reveal the function of histone lactylation during Senescent and demonstrate that this modification can be used as a novel marker of Senescent, and perhaps even a potential target for aging intervention.

ORGANISM(S): Homo sapiens

PROVIDER: GSE226006 | GEO | 2024/05/01

REPOSITORIES: GEO

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Histone lactylation antagonizes Senescent via facilitating gene-expression reprogramming [snRNA-seq]

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