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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [snRNA-seq]

ABSTRACT: Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [snRNA-seq]

PROVIDER: PRJNA938242 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR23605657_1.fastq.gz	Fastqsanger.gz
	SRR23605657_2.fastq.gz	Fastqsanger.gz
	SRR23605658_1.fastq.gz	Fastqsanger.gz
	SRR23605658_2.fastq.gz	Fastqsanger.gz
	SRR23605659_1.fastq.gz	Fastqsanger.gz

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [snRNA-seq]

Project description:Epigenetic alterations are among the prominent drivers of cellular senescence and/or aging, intricately orchestrating gene expression programs during these processes. Many studies have investigated the histone modification mechanisms that regulate cellular senescence and aging. In this study, we show that histone lactylation, an identified histone modification that integrates metabolic processes, epigenetic regulation of gene expression and cellular activities in response to internal and external cues, plays a pivotal role in counteracting senescence and mitigating dysfunctions of skeletal muscle in aged mice. Mechanistically, histone lactylation levels markedly decrease during cellular senescence but are restored under hypoxic conditions primarily due to elevated glycolytic activity. The enrichment of histone lactylation at promoters is essential for sustaining the expression of genes involved in the cell cycle and DNA repair pathways, thereby inhibiting cellular senescence. Furthermore, the modulation of enzymes crucial for histone lactylation, including p300 and HDAC1, leads to reduced histone lactylation and accelerated cellular senescence. Consistently, the suppression of glycolysis and the depletion of histone lactylation are also observed during skeletal muscle aging. Running exercise increases the levels of glycolysis and histone lactylation, which in turn upregulate key genes in the DNA repair and proteostasis pathways, thereby helping to preserve the proper function of skeletal muscle. Our study highlights the significant roles of histone lactylation in modulating cellular senescence as well as aging-related tissue function, suggesting that this modification may serve as an innovative biomarker for senescence and provides a promising avenue for antiaging intervention via metabolic manipulation.

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming

Project description:Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [CUT&Tag]

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [RNA-seq]

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [RNA-Seq II]

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [RNA-seq]

Project description:Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [RNA-seq]

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [CUT&Tag]

Project description:Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [CUT&Tag]

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [RNA-Seq II]

Project description:Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming [RNA-Seq II]

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Histone lactylation antagonizes senescence and skeletal muscle aging via facilitating gene expression reprogramming

Project description:This SuperSeries is composed of the SubSeries listed below.

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Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype

Project description:We found histological evidence for increased abundance of iron accumulating cells in association with fibrotic lung, kidney, and heart diseases in mice and humans. We showed that inducing iron accumulation by intratracheal iron delivery in mice is a potent inducer of inflammation, cellular senescence, and fibrosis. The aim of this study has been to understand the single cell dynamics of iron accumulation and the mechanics that link it to in vivo senescence and to fibrogenesis. To get deeper insight into how different cell types respond to iron accumulation, we performed single nuclei RNA sequencing (snRNA-seq) of lungs from mice which received a single intratracheal dose of iron 2 or 6 days prior to analysis, or PBS 6days prior to analysis (control).

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