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Folfirinox-dependent reprogramming of macrophages by primary pancreatic cancer CAFs

ABSTRACT: The pancreatic cancer tumor microenvironment is dominated primarily by cancer-associated fibroblasts (CAFs) and tumor associated macrophages (TAMs). The interecellular dialogue between CAFs and TAMs and the resulting impact on chemoresistance, specifically to Folfirinox, remains poorly understood. In this study, we sought to understand the impact of primary PDAC CAFs on macrophage reprogramming in a folfirinox-dependent manner and performed various cellular assays (viability, immunophenotyping, phagocytosis, secretory profile analysis) and transcriptomic analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE226448 | GEO | 2024/01/10

REPOSITORIES: GEO

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| EGAS00001006661 | EGA

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